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Seminar in Advanced Pharmacy 1 (PHRM601)

This course will consist of lectures given by faculty members, visiting scholars, and graduate students, followed by discussions that will cover the latest trends in research and pharmacy.

Seminar in Advanced Pharmacy 2 (PHRM602)

A continuation of the course Seminar in Advanced Pharmacy I, this course will consist of lectures given by faculty members, visitng scholars, and graduate students, followed by discussions that will cover the latest trends in research and pharmacy.

Major Optional

Advanced Pharmaceutical Intellectual Property (PHRM603)

This course will cover the importance and meaning of patent, national and international intellectual property, and know-how for prior art search. In addition, student will have a chance to practice for patent information search on R&&D medicine.

Advanced Microbiology I (PHRM6113)

Microbiology is actively researched, and the field is advancing continuously. It is estimated that only about one percent of the microorganisms present in a given environmental sample are culturable and the number of bacterial cells and species on Earth is still not possible to be determined, recent estimates indicate that it can be extremely high.

Advanced Microbiology II (PHRM6114)

Microbiology is actively researched, and the field is advancing continuously. Especially, this class of microbial pharmacals designed for pharmaceutical education including infectious disease and their therapy, host defense mechanism and drugs related with microorganisms.

Immunobiology I (PHRM6112)

This class covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo.

Immunobiology II (PHRM6115)

This class focus immune disease such as autoimmune disease or allergy. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has applications in several disciplines of science, and as such is further divided.

Infectious Pathogen (PHRM6116)

A pathogen or infectious agent is a microorganism in the widest sense, such as a virus, bacterium, prion, or fungus, that causes disease in its host; the host can be an animal (including humans), a plant, or even another microorganism. There are several substrates including pathways wherein pathogens can invade a host; the principal pathways have different episodic time frames, but soil contamination has the longest or most persistent potential for harboring a pathogen.

Vaccinology (PHRM6117)

A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe, its toxins or one of its surface proteins. This class covers currently available vaccine and their future.

Autoimmune Disease (PHRM6118)

Autoimmune diseases arise from an inappropriate immune response of the body against substances and tissues normally present in the body. In other words, the immune system mistakes some part of the body as a pathogen and attacks its own cells. This may be restricted to certain organs or involve a particular tissue in different places. This class covers immunopathology and therapy of autoimmune disease.

Immunotherapy (PHRM6119)

Immunotherapy is a medical term defined as the "treatment of disease by inducing, enhancing, or suppressing an immune response". Immunotherapies designed to elicit or amplify an immune response are classified as activation immunotherapies. While immunotherapies that reduce or suppress are classified as suppression immunotherapies. This class covers currently available immunotherapeutics and their future.

Tumor Immunology (PHRM6120)

Cancer immunology is the study of interactions between the immune system and cancer cells. It is also a growing field of research that aims to discover innovative cancer immunotherapies to treat and retard progression of this disease. This class covers immune interaction with tumor and currently available anti-cancer immunotherapeutics.

Cellular Immunology (PHRM6121)

The study of the molecular and cellular components that comprise the immune system, including their function and interaction, is the central science of immunology. This class covers the immunological function of cells, organs and systems not normally associated with the immune system, as well as the function of the immune system outside classical models of immunity.

Advanced Molecular & Cellular Biology 1 (PHRM6111)

This class offers the first 12 topics covering a wealth of cell and molecular biology (Molecular technology, transcription, DNA-protein interaction, epigenetics). It will provide in?depth critical discussion of primary literature and emphasize the experimental strategy and the data that led to the conclusions, rather than just the conclusion themselves.

Advanced Molecular & Cellular Biology 2 (PHRM6122)

This class offers the second 12 topics covering a wealth of cell and molecular biology (posttranscriptional modification, translation, DNA replication). It will provide in?depth critical discussion of primary literature and emphasize the experimental strategy and the data that led to the conclusions, rather than just the conclusion themselves.

Advanced Molecular Biomedicine (PHRM6123)

The course will provide new clinical and basic research findings in the areas of gene therapy and molecular medicine. In particular, this course will briefly review the fundamental principles vital to understanding the human genome, gene regulation and transcription, and various molecular biology techniques and more importantly, will introduce how these principles have been applied to the diagnosis and treatment of hematological, cardiovascular, neurological, infectious human disorders and cancers.

Gene Therapy (PHRM6124)

The course is designed to give students knowledge of the molecular basis of gene therapy and various gene delivery systems. In addition, students will comprehend different gene therapy strategies for the treatment of various diseases including, cardiovascular disease, infectious disease, neural diseases, hematopoietic disease, and cancer.

Advanced Stem Cell Biology 1 (PHRM6125)

Stem cell biology lies at the intersection of developmental/cell biology and medicine. It holds great promise for regenerative medicine. This course will cover a broad range of topics relevant to adult and embryonic stem cells, such as how they were identified, purified, and characterized. In addition, it will deal with the underlying mechanism how stem cells exhibit pluripotency and self-renewal properties.

Advanced Stem Cell Biology 2 (PHRM6126)

Stem cell biology lies at the intersection of developmental/cell biology and medicine. It holds great promise for regenerative medicine. This course will cover a broad range of topics relevant to role of adult and embryonic stem cells during tissue repairing and and organ development process, and their therapeutic application. In addition, it will deal with key experimental methods used in stem cell research fields.

Vascular Biology 1 (PHRM6127)

This course will expose students to both developmental and pathological aspects of vascular biology. The central goal of the course is to provide basic understanding of important aspects of vascular biology emphasizing the methods by which this knowledge is obtained using a variety of experimental approaches and model organisms. In particular, the first series of vascular biology course will focus on vascular development and the use of model systems to study vascular processes.

Vascular Biology 2 (PHRM6128)

This course will expose students to both developmental and pathological aspects of vascular biology. The central goal of the course is to provide basic understanding of important aspects of vascular biology emphasizing the methods by which this knowledge is obtained using a variety of experimental approaches and model organisms. In particular, the second series of vascular biology course will focus on the molecular and cellular mechanisms regulating angiogenesis, atherosclerosis,and thrombosis.

Stem Cell Biology for Health and Disease (PHRM615)

This course will cover how stem cells are involved in maintaining the normal turnover and homeostasis of various tissues and organs. In addition, it will present an up-to-date overview on how stem cells (adult stem cell, embryonic stem cells, induced pluripotent stem cells) have been applied for the treatment of human diseases.

Drug Target Discovery (PHRM6110)

This course will provide the comprehensive knowledges essential in identifying and validating the cellular target involved in disease development and progress. In particular, this course will provide several case studies to emphasize how bioinformatic data have been mined and applied to find new disease-associated genes or proteins and estimate their potentials as drugaable targets.

Advanced Human Physiology 1 (PHRM622)

Physiology deals with the principle of each organ and their roles in human body and it is also designed to make students understand the mechanisms for the maintenance of the body homeostasis.

Advanced Human Physiology 2 (PHRM623)

Physiology deals with the principle of each organ and their roles in human body and it is also designed to make students understand the mechanisms for the maintenance of the body homeostasis.

Molecular Pathophysiology (PHRM618)

The course deals with the pathophysiology of each organ system. This course of study will contain the causes, symptoms, pathogenesis, diagnosis, treatment, and prognosis of organ specific disease, This course also includes the studies on the evaluation of the animal models of various diseases and further on the design and establishment of a new animal disease models.

Regulation and Mechanism of Cell Death (PHRM619)

This course will cover overview of cell death, the importance and meaning of cell death in diseases. This course will also cover signaling mechanisms of cell death in various diseases including cardiovascular disease, neurodegenerative disease, liver disease and inflammatory disease.

Animal Pathophysiology (PHRM624)

Animal Pathophysiology deals with the principle of organ diseases (brain disease, cardiovascular, hepatic and allergic diseases) in experimental animal.

Advanced Cell Physiology (PHRM625)

Advanced Cell Physiology deals with the principle of carious diseases according to each organs and their pathogenesis, pathology and pathophysiology at cellular level.

Advanced Cardiovascular Physiology (PHRM626)

Advanced Cardiovascular Physiology deals with the anatomy and physiological principle of cardiovascular systems.

Hemodynamic Pathophysiology (PHRM627)

Hemodynamic Pathophysiology deals with the principle of various cardiovascular diseases associated with hemodynamic dysfunction and their pathogenesis, pathology and pathophysiology.

Advanced Neutraceutical Physiology 1 (PHRM628)

Advanced Neutraceutical Physiology I deals with the principles of physiological functions of the food or food product that reportedly provides health and medical benefits, including the prevention and treatment of diseases (hypertention, high cholesterolemia. heart disease, liver disease).

Advanced Neutraceutical Physiology 2 (PHRM629)

Advanced Neutraceutical Physiology II deals with the principles of physiological functions of the food or food product that reportedly provides health and medical benefits, including the prevention and treatment of diseases (allergy, obesity, diabetes).

Advanced Molecular Pharmacology (PHRM611)

Advanced pharmacology provides students with topics on practical aspects and case studies on new drug discovery in the stand point of molecular, cellular, and systems pharmacology. Topics include: recent trends in pharmacological target discovery for new therapeutics; case study for first-in-class drug discovery.

Advanced Pharmacokinetics 1 (PHRM621)

To understand the processes of drug’s absorption, distribution, metabolism and excretion in view of kinetic mechanism and to learn the advanced knowledge of pharmacokinetic principles for determination of dose, interval and dosage to establish more effective and safer therapeutics.

Advanced Pharmacokinetics 2 (PHRM6210)

To understand the processes of drug’s absorption, distribution, metabolism and excretion in view of kinetic mechanism, to learn the pharmacokinetic consideration of disease state and to review and discuss the recent published paper for determination of dose, interval and dosage to establish more effective and safer therapeutics.

Pharmacokinetic Data Analysis (PHRM6211)

To understand the processes of drug’s absorption, distribution, metabolism and excretion in view of kinetic mechanism, to consider all the factors (dosage, drug interaction, patients’ disease state etc) and to analyze the pharamcokinetics.

Advanced Drug Metabolism (PHRM6212)

To understand the biotransformation of drugs, expression of drug metabolizing enzyme and regulation mechanism and to learn in vivo/in vitro mechanism fo drug metabolism and factors to affect drug metabolism.

Advanced Clinical Pharmacokinetics (PHRM6218)

To understand required knowledge and method for evaluation of therapeutic and application of pharmacokinetic principle and to learn quantitative therapeutic design for pharmacokinetic parameters, dosage adjustment and expectation of plasma concentration based on each therapeutic monitoring drug.

Advanced Oncology (PHRM6213)

To understand the basic morphological and biological characteristics, molecular carcinogenic property, to learn cancer epidemiology, carcinogenesis, genetic change, oncoges, tumor suppress genes, cell cycle, autophagy and tumor metastatic mechanisms and to apply for chemotherapeutic methodology.

Advanced Drug Interaction (PHRM6214)

To understand the factors to affect the in vitro/in vivo drug-drug interaction in view of pharmacokinetics (absorption, distribution, metabolism and excretion) and side effects due to drug-drug interaction and to analyze and evaluate drug-dug interaction results.

Epigenetics (PHRM6215)

To understand the basic concept of DNA methylation and relationship bewteen gene and protein expression changes and disease and to study the basic knowledge of cancer epigenetics, regulation mecanism of DNA methylation and epigenetic methodology.

Advanced Clinical Pharmacology (PHRM6216)

To understand pharmacokinetic and pharmacodynamic principles in the process of drug effect, factors to determine dose-response relationship in the drug therapy and factors to cause a variety of drug response and to study the therapeutic regimen focusing on dosage based on need and principle of drug therapy considering effect-adversed effects.

Preclinical Pharmacokinetic Methodology (PHRM6217)

To study the basic preclinical pharmacokinetic method for clinical study through understanding in vitro test (physiochemical property and plasma protein binding etc) and in vivo test (pharmacokinetic study in various speices and animal scal-up) in the new drug development and to apply for the clinical trials.

Advanced Instrumental Analysis 1 (PHRM6315)

This course provides the theories and applications of instrumental analysis for characterization of structure of small molecular pharmaceuticals derived from organic synthesis or natural products. Instrumental analysis techniques in this course include NMR, IR, UV, MASS, and other spectroscopy.

Advanced Instrumental Analysis 2 (PHRM6316)

This course provides the theories and applications of instrumental analysis of biological macromolecules including protein, lipid, and biopolymers. Instrumental analysis techniques in this course include electrophoresis, imaging, and flow cytometry.

Advanced Pharmaceutical Analysis 1 (PHRM6314)

This course will cover the principles, methods, and applications of various analytical techniques for drug analysis. This course includes analytical method development, approaches, and validation which are applicable to various fields of pharmaceutical sciences.

Advanced Pharmaceutical Analysis 2 (PHRM6317)

This course will cover various analytical techniques depending on physicochemical properties of analytes and analytical derivatization techniques for sensitive detection and analysis. Introduction and understanding of emerging techniques and trends in drug analysis.

Advanced Quality Control of Drugs (PHRM6318)

Advanced quality control of drugs will provide principals and approaches for development of quality control method in drug production.

Analysis of Pharmaceutical Preparations (PHRM6319)

This course covers the analysis of pharmaceutical preparations during the entire pharmaceutical manufacturing process from the quantitative and qualitative analysis of raw materials to standardization, manufacturing, equipmenting, and final product assays and stability studies will be taught.

Sample Preparation (PHRM6320)

This course will cover the principals of various sample preparation techniques including SPE, LLE, SFE, and headspace sampling. This course will help students choosing appropriate sample preparation techniques to concentrate analytes of interest and minimize interference materials in samples.

Mass Spectrometry (PHRM6321)

This course will focus on mass spectrometry including principals, instrumentations (interface, ion source, mass analyzers), and representative applications such as proteomics and metabolomics.

Chromatography (PHRM6322)

This course will cover various chromatographic techniques and separation principals including adsorption, partition, size-exclusion, ion-exchange, and affinity chromatography. And also, this will help students choosing appropriate chromatographic techniques depending on physicochemical properties of various analytes.

Pharmacometabolomics (PHRM6323)

This course deals with the analytical methods of drugs which are used in the preclinical tests. It covers how to analyze drugs and their metabolites from various biological matrix such as urine, plasma, and tissues based on pharmaceutical analysis skills.

Special Topics in Natural Products 1 (PHRM6324)

This course deals with the de novo synthesis of secondary metabolites in plants in the context of chemical synthesis and enzymatic (genetic) approaches.

Special Topics in Natural Products 2 (PHRM6325)

This course deals with the de novo synthesis of secondary metabolites in plants in the context of chemical synthesis and enzymatic (genetic) approaches.

Current Topics on Biological Activity of Natural Products 1 (PHRM6326)

This course uncovers the various techniques and rationales for assess high-value bioactive natural products and study representative methods.

Current Topics on Biological Activity of Natural Products 2 (PHRM6327)

This course uncovers the various techniques and rationales for assess high-value bioactive natural products and study representative methods.

Separation Techniques for Bioactive Natural Products 1 (PHRM6313)

This course uncovers the separation techniques and identification of naturally-occurring bioactive materials. The courses includes: 1) pre-screening of candidate plant or molecules, 2) Activity-guided fractionation and separation skills, 3) animal cell culture system as a model assay tools, 4) plant cell culture for alternative resources of secondary metabolites.

Separation Techniques for Bioactive Natural Products 2 (PHRM6328)

This course uncovers the separation techniques and identification of naturally-occurring bioactive materials. Target molecules are classified as follows: 1) oncogenic materials and Tumor suppressors, 2) antiinflammatory compounds, 3) contraceptives, 4) antibiotics, 5) prostaglandins, 6) phytoalexins, pheromones and phytohormones, 7) technical aspects of elucidating target molecules.

Advanced Pharmacognosy (PHRM633)

The course enables students to learn recent research trends in medicinal plant research. Topics in the course include: domestic medicinal plants and their pharmacological activities; applications of medicinal plants in new drug discovery; development of medicinal plant drugs; taxonomy, usage and application of medicinal plants.

Worldwide Natural Resources (PHRM6329)

This course uncovers the diversity of natural products widely used worldwide. Natural products considered as a valuable resources to develop a new drug in biomedical society including Korea.

Researches for Bioactive Natural Resources 1 (PHRM6330)

This course uncovers the diversity of natural products widely used worldwide. Natural products considered as a valuable resources to develop a new drug in biomedical society including Korea.

Researches for Bioactive Natural Resources 2 (PHRM6331)

Advanced techniques to isolate, identify natural products currently and representative examples to adopt the techniques.

Advanced Pharmaceutical Manufacturing Chemistry 1 (PHRM641)

In this lecture, we will study on the advanced organic reactions that have been utilized in synthesis of various drug-synthesis. By understanding the synthetic methods through this lecture, it could be applied them to development of the new drug-synthesis.

Advanced Pharmaceutical Manufacturing Chemistry 2 (PHRM642)

In this lecture, we will study on the advanced organic reactions that have been utilized in synthesis of various drug-synthesis. By understanding the synthetic methods through this lecture, it could be applied them to development of the new drug-synthesis.

Total Synthesis of Natural Products (PHRM643)

Natural products have been important target molecules in organic chemistry. Understanding of synthesis of natural products should be helpful to understand and develop the synthesis of new natural products that would be a very potential in new natural product drug. In this lecture, we will focus on the understanding of the previous synthesis of natural product by investigating and discussing papers on them.

Synthesis of Pharmaceutical Natural Product Drugs (PHRM644)

Natural products are medicinally important active ingredients, or organic compounds, and a source of new drug-discovery especially. Understanding of synthesis of natural product drug should be helpful to develop the new synthetic drug discovery. In this lecture, we will focus on the understanding of the previous synthesis of natural product drug by investigating and discussing papers on them.

Discovery and Development of Synthetic New Drug (PHRM645)

Organic synthesis of new drug entity is challenged by the creation of novel, biologically active, safe and suitably targeted molecules and the improvement of lead compounds, as well as by the need to scale up compound quantities for safety and clinical studies. In this lecture, we will focus on the understanding of synthetic strategies on the complex molecules and planning of new synthetic route to biologically important molecules by studying previous related articles.

Stereochemistry in Organic Chemistry (PHRM646)

In this lecture, we will study the stereochemistry in organic chemistry including methods for preparation of optically pure organic molecules and determining of the result of stereochemical reactions and apply to the stereoselective synthesis of new chiral molecules by understanding of stereoselective reactions.

Mechanisms of Drug Action (PHRM6310)

This course deals with the principles of drug action and the pharmacological activities of various classes of drugs. The major focus is on the molecular mechanisms of drug action, towards rational approaches to drug design utilizing mechanistic information. Students will have a knowledge of the mode of action in major classes of therapeutic agents with a detailed discussion of one or more prototypes of each drug class.

Advanced Medicinal Chemistry 1 (PHRM647)

we will study on the process of new drug discovery, their in vivo/in vitro activities, and their intracellular mode of action to optimize new drug candidates.

Advanced Medicinal Chemistry 2 (PHRM648)

We will study on the process of new drug discovery, their in vivo/in vitro activities, and their intracellular mode of action to optimize new drug candidates.

Advanced Pharmaceutical Chemistry (PHRM649)

In this lecture, we will study on the recent research results on the synthesis of bilogical active products and hot topics in pharmaceutical chemistry by lecture and presentation.

Structure-Activity Relationship (PHRM6410)

The structure-activity relationship(SAR) is the relationship between the chemical or 3D structure of a molecule and its biological activity. The analysis of SAR enables the determination of the chemical groups responsible for evoking a target biological effect in the organism. In this lecture, we will focus the understanding of SAR and design the optimal structure of biological active small molecules leading to design new drug candidates.

Bioorganic Chemistry 1 (PHRM6411)

Bioorganic chemistry is a rapidly growing scientific discipline that combines organic chemistry and biochemistry. While biochemistry aims at understanding biological processes using chemistry, bioorganic chemistry attempts to expand organic-chemical researches toward biology. In this lecture, we will study intracellular reaction between chemical molecules and their binding-enzymes to understand the design of new drug.

Bioorganic Chemistry 2 (PHRM6412)

Bioorganic chemistry is a rapidly growing scientific discipline that combines organic chemistry and biochemistry. While biochemistry aims at understanding biological processes using chemistry, bioorganic chemistry attempts to expand organic-chemical researches toward biology. In this lecture, we will study intracellular reaction between chemical molecules and their binding-enzymes to understand the design of new drug.

Advanced Chemical Biology 1 (PHRM6413)

With the advent of combinatorial chemistry and other synthetic technologies, it is feasible to prepare large collections of synthetic organic molecules. These libraries are useful in providing molecules that can be used to probe relevant biological pathways. Therefore, in this lecture, we will study on the identifying modulators of biological processes.

Advanced Chemical Biology 2 (PHRM6414)

With the advent of combinatorial chemistry and other synthetic technologies, it is feasible to prepare large collections of synthetic organic molecules. These libraries are useful in providing molecules that can be used to probe relevant biological pathways. Therefore, in this lecture, we will study on the identifying modulators of biological processes to utilize the development of new drug discovery.

Advanced Enzyme Kinetics (PHRM617)

This course will cover various analytical techniques depending on physicochemical properties of analytes and analytical derivatization techniques for sensitive detection and analysis. Introduction and understanding of emerging techniques and trends in drug analysis.

Advanced Drug Design (PHRM631)

This course focuses on the design principles of therapeutic ligands from the structure-based and mechanism-based methods. It deals with the physical, chemical and pharmaceutical properties of drugs along with current methodologies involved in the drug discovery process. Topics include QSAR optimization methods, X-ray or NMR structure based methods, and combinatorial techniques. Drug-target interactions at the molecular level will be also examined using 3D-visualization techniques.

Environmental Disease (PHRM6510)

Environmental disease is disease caused by environmental factors that are not transmitted genetically or by infection. This course will introduce the general principles of environmental diseases. Topics will cover the adverse effects of the environmental factors such as stress, physical and mental abuse, diet, toxins, pathogens, radiation, and toxic chemicals. Special emphasis will be placed on environmental diseases genetically predisposed to a particular condition.

Advanced Preventive Pharmacy (PHRM658)

This course will review the latest literature on preventive pharmacy, with an emphasis on the disposition of xenobiotics, toxic mechanism, biological self defense mechanism, nutrition and diseases, food safety and hygienic analysis.

Molecular Toxicology (PHRM659)

Molecular toxicology delas with the toxic responses of xenobiotics at the molecular level. This course will introduce the metabolic activation (biotransformation) of xenobiotics, interaction of xenobiotics with genes, gene expression and signal transduction as well as the health effects, the sources of free radicals generated in the cells and recent technology to detect free radicals, and provide a number of examples for toxic insults resulting from free radicals.

Preventive Nutrition (PHRM6511)

This lecture provides the graduate students with core knowledge of preventive nutrition and recent informations on up-to-date researches indicating that the risk of the major life style diseases affecting aged adults can be prevented or at least delayed, with nutritional approaches.

Biomarkers of Environmental Diseases (PHRM6512)

Molecular biomarkers have long been recogniged as invaluable tools for identifing and preventing human disease. The potential of molecular biomarkers is especially high in relation to preventing environmental disease. This lecture reviews characteristics of useful biomarkers, criteria that can be used during biomarker development, and mechanisms promoting progress in biomarker research.

Pollutants and High-Risk-Groups (PHRM6513)

The intention of this lecture is to make the students aware the effects of pollutants on the hypersusceptible population of the pollution so that more informed decisions can be made in the fields of environmental and occupational health. For this purpose this lecture reviews various biological factors in detail, which predispose individuals to toxic effects of pollutants.

Topics in Chemoprevention (PHRM6514)

This lecture provides graduate students with important knowledge on background, rationale, and selection of chemoprevention agents as well as design, implementation and evaluation of chemoprevention studies. This lecture also offer the students up to date information of chemoprevention through comprehensive and critical review of current literatures.

Nutrition and Chemical Toxicity (PHRM6515)

This lecture provides graduate students with the systematic knowledge on effects of nutritional status on chemicals toxicities including chemical carcinogenesis and all stsudents will be exposed to gain up-to-date informations through comprehensive and critical review of current literatures.

Pharmaceutical Molecular Genetics (PHRM6516)

In this lecture graduate students will gain an understanding of the principles, terminology and techniques of molecular genetics important for the aspects of biopharmaceutical and preventive pharmacal research. Students will acquire fundamental skills that are necessary for reading current literature, critical analysis and for use in their own research.

Noxious Biological Reaction and Cell Signaling (PHRM6517)

This lecture provides graduate students with systematic knowledge about signal transduction pathways related to cell growth, proliferation, death and survival to understand the mechanisms of tumorigenesis and other toxic biological reactions. This lecture also reviews recent efforts of prevention of environmental cancers and anticancer drug development targeting signal transduction pathway.

Cancer Metabolism (PHRM6518)

This lecture provides graduate students with systematic knowledge about the emerging cancer metabolism field to understand the interaction between metabolism and tumorigenesis and recent efforts of anti-cancer drug development targeting cancer metabolism and their application to the prevention of environmental cancers.

Stem Cell Biology for Health and Disease (PHRM6519)

Not all medicines but many medicines can be affected by what you eat and when you eat it. Food and drug interaction may produce unexpected results or cause other health problems. This lecture provides graduate students with the knowledge about core knowledges on food and drug interactions and students gain up-to-date informations through comprehensive review of current literatures.

Environmental Epidemiology (PHRM6520)

This lecture is designed to provide the graduate students majored in preventive pharmacy with core knowledge and skills in environmental epidemiology, and to prepare students to put epidemiologic concepts and methods into public health practice, including research studies in public health and the interpretation of scientific evidence relevant to public health.

Special Studies in Preventive Pharmacy (PHRM6521)

In this course students will present and discuss recent published articles in preventive pharmacy.Students learn about recent knowledges in the field of preventive pharmacy and gain the skills of critical evaluation and discussion of scientific literatures. In addition,this course is designed to develop presentation and grant-writing skills. All students will be exposed to develop research projects and present them to the graduate students and professors of the department of preventive pharmacy.

Advanced Pharmacotherapy - Cardiovascular Disorders (PHRM6522)

"Advanced pharmacotherapy ? Cardiovascular disorders” will focus on the use of drug therapy to treat patients with cardiovascular disorders. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Advanced Pharmacotherapy - Respiratory Disorders (PHRM6523)

"Advanced pharmacotherapy?Respiratory disorders” will focus on the use of drug therapy to treat patients with respiratory disorders. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Advanced Pharmacotherapy - Renal Disorders (PHRM6524)

"Advanced pharmacotherapy?Renal disorders" will focus on the use of drug therapy to treat patients with renal disorders. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Advanced Pharmacotherapy - Endocrinologic Disorders (PHRM6525)

"Advanced pharmacotherapy?Endocrinologic disorders" will focus on the use of drug therapy to treat patients with endocrinologic disorders. This course will focus on the pharmaceutical care and the practical implementation of knowledge.Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Advanced Pharmacotherapy - Infectious Diseases (PHRM6526)

"Advanced pharmacotherapy-Infectious Diseases" will focus on the use of drug therapy to treat patients with infectious diseases. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Advanced Pharmacotherapy - Oncologic Disorders (PHRM6527)

"Advanced pharmacotherapy-Oncologic disorders" will focus on the use of drug therapy to treat patients with oncologic disorders. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Advanced Pharmacotherapy - Psychiatric Disorders (PHRM6528)

"Advanced pharmacotherapy-Psychiatric disorders" will focus on the use of drug therapy to treat patients with psychiatric disorders. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Advanced Pharmacotherapy - Neurologic Disorders (PHRM6529)

"Advanced pharmacotherapy-Neurologic disorders" will focus on the use of drug therapy to treat patients with neurologic disorders. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Advanced Pharmacotherapy - Arthritic Disorders (PHRM6530)

"Advanced pharmacotherapy-Arthritic disorders" will focus on the use of drug therapy to treat patients with arthritic disorders. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Advanced Pharmacotherapy - Critical Care (PHRM6531)

"Advanced pharmacotherapy-Critical care" will focus on the use of drug therapy to treat patients in critical care. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy.

Advanced Pharmacotherapy - Solid Organ Transplantation (PHRM6532)

"Advanced pharmacotherapy-Solid organ transplantation" will focus on the use of drug therapy to treat patients with organ transplantation. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Advanced Pharmacotherapy – Pediatrics (PHRM6533)

"Advanced pharmacotherapy-Pediatrics" will focus on the use of drug therapy to treat pediatric patients. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Advanced Pharmacotherapy – Geriatrics (PHRM6534)

"Advanced pharmacotherapy-Geriatrics" will focus on the use of drug therapy to treat elderly patients. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Clinical Nutrition (PHRM6535)

Clinical nutrition will focus on the use of drug therapy to treat patients with nutritional disorders. This course will focus on the pharmaceutical care and the practical implementation of knowledge. Students will discuss and apply in the practice how to assist other caregivers in the development of a rational plan of drug therapy for a patient, and to evaluate existing plans of therapy and suggest alternative therapeutic treatments.

Medication Use Evaluation (PHRM6536)

This course will provides information on the concept of medication use evaluation (MUE), a quality assurance method that has been shown to be effective in identifying medicine use problems. Students will discuss the process for implementing and performing a broad-based, ongoing, and systematic MUE in order to improve medication use.

Clinical Study Methods (PHRM656)

This course make students practice with clinical study. They learn to design clinical study using clinical data collected in the practice. They establish the hypothesis to question raised in the clinical practice. The area may include the pharmacotherapy, clinical pharmacokinetics, and clinical service. The variables to assess outcomes include clinical lab tests, clinical events, quality of life, patient reported outcomes and adverse drug reactions.

Advanced Drug Information (PHRM6537)

The goal of this course is preparation of the students as an effective drug information contributor to provide an integral component of pharmaceutical care, which seeks to improve the effective, safe, and cost-effective use of medications.

Advanced Pharmacy Statistics (PHRM654)

Advanced pharmacy statistics course provide statistical theory with the statistical package of SAS or SPSS. The advanced course covers the categorical data, multiple regression, survival analysis and meta analysis. The prerequisite knowledge is a descriptive statistics, t-test, ANOVA, correlation, chi-square test for categorical data and regression.

Advanced Pharmacoeconomics (PHRM657)

The advanced pharmacoeconomics provide the analysis of the cost of drug therapy The methods of pharmacoeconomics includes cost-minimization, cost-benefit, cost-effectiveness and cost-utility analysis. Students learn how to incorporate pharmacoeconomics into pharmacotherapy and build a economic model using decision analysis, Marcov model and quality adjusted life year.

New Drug Discovery && Pharmacogenomics (PHRM664)

The course enables students to have working knowledge on the application of pharmacogenomics and toxicogenomics in new drug discovery. Topics include: drug discovery in post-human genome projects era; pharmacogenomics and toxicogenomics in drug discovery; regulations in US FDA regarding to pharmacogenomics; biomarker development in drug discovery.

Cosmeceuticals and Systems Skin Biology (PHRM663)

This course covers the recent trends in pharmacological and toxicological sciences for the development of cosmeceuticals. The course enables to graduate students to have working knowledge on systems skin biology associated with the development of anti-wrinkles, anti-melanogenic cosmetic materials, and cosmeceuticals to improve skin barrier, etc. In addition, this course will cover the recent trends in the development of alternative toxicological testing for cosmetics.

Pharmaceutical Bioinformatics (PHRM665)

The course covers practical aspects of bioinformatics in pharmaceutical industry. The course enables to graduate students to have working knowledge on exploiting public microarray databases like Gene Expression Omnibus in National Center for Biotechnology Information to perform data-mining for new drug discovery. This course will provide a case study opportunity to each student to analyze clinical databases which will be applied to find new drug targets.

Tissue Engineering for New Drug Discovery (PHRM666)

The course enables to graduate students to have working knowledge on application of tissue engineering in drug development in pharmaceutical industry. This course will focus on liver tissue engineering. Students will have opportunities to learn application of hepatocyte stem cells and biomaterials on liver tissue engineering and also to study the importance of cell mechanics and biocompatible devices in tissue engineering.

Advanced Alternative Safety Test Methods (PHRM667)

This course will cover knowledge on alternative safety test methods for skin irritation, skin sensitization, and photosensitivity, etc. The course enables to graduate students to have working knowledge on the development of new alternative safety testing methods for cosmeceutical omics based on skin toxicology.

Drug Discovery for Metabolic Diseases (PHRM668)

This course will cover recent trends in the development of the first-in-class anti-diabetic drugs and anti-obesity drugs. The course enables to graduate students to have working knowledge on development of novel drugs to treat type 2 diabetes and obesity.

Advanced Anti-inflammatory Drugs (PHRM669)

This course will cover the recent trends in anti-inflammatory drug discovery. The course enables to graduate students to have working knowledge on the relationship between inflammation and type II diabetes, and between inflammation and cancer.

Pharmacological Receptors (PHRM612)

This course covers the molecular mechanisms of drugs according to their ligand-receptor interactions. The course enables students to have working knowledge on binding kinetic parameters for drug-receptor interaction and their applications in drug discovery. Special topics include: receptors in cardiovascular-renal drugs; receptors in drugs used to treat inflammation and diseases of the blood; receptors in endocrine drugs, and etc.

Advanced Pharmacological Evaluation Technology for Cosmetics (PHRM6610)

This course will cover the recent trends in pharmacological evaluation methods for anti-wrinkle and/or whitening cosmetics. The course enables to graduate students to have working knowledge on the development of scientific skin concepts for new cosmetic products.

Advanced Physical Pharmacy (PHRM637)

Advanced physical pharmacy enables students to learn practical aspects in the application of physical pharmacy theories to pharmaceutical products. Topics in the course include: applications of physicochemical properties of drugs and drug reaction to pharmaceutical formulations and drug delivery system; applications of physicochemical properties of biological systems in dosage form design.

Biophysical Pharmacy (PHRM662)

Understand the physicochemical properties of drug and study of biotechnology-related properties of physical pharmacy.

Structural Determination of Biomolecules (PHRM6611)

Understand the fundermental principles and methods for the determination of structure of biomolecules (protein, peptide) using NMR and X-ray crystallography.

Advanced Structure-Based Drug Discovery (PHRM6612)

Understand the Structure-based drug discovery (SBDD) : process, theoretical background, techniques, examples of drug discovery, etc.

Techniques in Physical Pharmacy (PHRM6613)

Understand the current researches of physical pharmacy. Graduate students will present and discuss about research papers related to their researches.

Advanced Dosage Formulation (PHRM661)

Understand and utilize the properties of various excipients and principles of drug formulations for the application in drug delivery system.

Preformulation (PHRM6614)

Understand and utilize various physicochemical properties of drugs for drug development.

Sciences of Pharmaceutical Excipients (PHRM6615)

Understand and utilize the principles of pharmaceutical excipients and the usage in drug development.

Polymer Science in Pharmacy (PHRM6616)

Understand the basic principles, manufacturing process, physicochemical properties of various polymers to apply for drug development.

Advanced Pharmaceutics (PHRM6617)

Understand and utilize the properties of various formulations and drug delivery systems.

Advanced Biopharmaceutics (PHRM6618)

Study the release mechanisms, bioavailability, equivalency of the formulation and understand physicochemical properties of drugs which is essential for drug development and evaluation.

Advanced Pharmaceutical Manufacturing (PHRM6311)

This course will cover the principles and application of recent manufacturing equipments and processes such as drying, coating, mixing, milling and tableting to prepare the advanced drug products and formulations in pharmaceutical industries. The graduate students also practice the principles and utilization of manufacturing equipment and processes for high standard R&D.

Chronopharmaceutics (PHRM6619)

Understand and utilize the change of pharmacological efficacy and pharmacokinetics of drugs by administration time or biorhythm in drug development.

Drug Targeting (PHRM6620)

Study various formulations and drug delivery systems to effectively target drugs in order to maximize efficacy of drugs while minimizing the side effects.

Advanced Drug Delivery System (PHRM6621)

Study the principels, mechanisms, clinical applications of advanced drug delivery system including various formulations and nano drug delivery system.

Nanopharmaceutics (PHRM6622)

Study the nano-technology and behavior of nanoparticles in human body to utilize nano-technology for pharmaceutical applications.

Drug Transporter (PHRM6623)

Study the principles of membrane transport, p-Glycoprotein efflux/transprters, and drug delivery system.

Coating Technology (PHRM6624)

Understand the film technology used for various drug development especially about the film materials, film formation, and the principles of coating technology used for advanced drug delivery.

Applied Dispersion System (PHRM6312)

In the preparation of drug products, various excipients and drug should be combined and processed. Thus, the interface between two materials is present so that the scientific principles and understanding of interfacial phenomena are very important. This course covers for graduate students to educate theory and principles, rheology and physicochemical properties of dispersion system, utilization of surfactants and preparation and application of diverse dispersion systems (emulsion, microemulsion, polymeric microparticles, lipid emulsion, liposomes) in pharmaceutical R&D.

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